Anaphylaxis: Anaphylaxis has long been described with codeine, on the list of elements in promethazine HCl and codeine phosphate oral Option.
Amplified tension in the head (improved intracranial pressure). Prevent the use of Promethazine Hydrochloride and Codeine Phosphate Oral Option In case you have a head injuries or are instructed that you've got improvements from the tissue of your respective brain (Mind lesions) or improved stress inside your head.
Your healthcare provider will inform you the amount Promethazine with Codeine Oral Answer to consider and when to take it. Will not change your dose with no speaking to your healthcare supplier.
Selling or gifting away Promethazine Hydrochloride and Codeine Phosphate Oral Remedy may possibly damage Other individuals, and is particularly against the regulation. Notify your healthcare supplier Should you have ever abused or been dependent on Alcoholic beverages, prescription medicines or Road medications.
are breastfeeding or want to breastfeed. Codeine passes into your breast milk and may cause significant Uncomfortable side effects within your toddler such as elevated sleepiness, respiration difficulties (respiratory melancholy), and Dying. It's not necessarily recognized if promethazine can go into your breast milk.
Results within the Cardiovascular Technique Codeine makes peripheral vasodilation which may end in orthostatic hypotension or syncope. click here Manifestations of histamine release and/or peripheral vasodilation could incorporate pruritus, flushing, crimson eyes and sweating and/or orthostatic hypotension.
Use warning When contemplating the usage of promethazine HCl and codeine phosphate oral solution in people sixty five decades of age or older.
For instance, quite a few reported situations of Dying occurred in the submit-operative interval adhering to tonsillectomy and/or adenoidectomy, and many of the children experienced evidence of remaining extremely-quick metabolizers of codeine. Also, young children with obstructive snooze apnea who will be treated with codeine for submit-tonsillectomy and/or adenoidectomy soreness may be specifically sensitive to its respiratory depressant influence. Due to chance of everyday living-threatening respiratory despair and Dying:
MAOI Interaction Inform people to not consider promethazine HCl and codeine phosphate oral Alternative although utilizing or within 14 times of stopping any medicine that inhibit monoamine oxidase.
Medical Considerations Infants subjected to promethazine HCl and codeine phosphate oral Resolution by means of breast milk needs to be monitored for excess sedation and respiratory despair.
Revealed research with codeine have described inconsistent conclusions and possess essential methodological restrictions (see Knowledge). There are reports of respiratory depression when codeine is utilized all through labor and supply (see Medical Things to consider).
There aren't any obtainable info with promethazine HCl and codeine phosphate oral solution use in Expecting Girls to tell a drug-affiliated chance for adverse developmental results.
Acute or severe bronchial bronchial asthma in an unmonitored location or in absence of resuscitative gear. (4)
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complicated, demanding very careful thought of the consequences about the guardian drug, codeine, and also the Lively metabolite, morphine.